Ontology highlight
ABSTRACT:
SUBMITTER: Hu W
PROVIDER: S-EPMC5288155 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Hu Wenxian W Jia Yunlu Y Xiao Xiangsheng X Lv Kezhen K Chen Yongxia Y Wang Linbo L Luo Xiao X Liu Tianze T Li Wenbin W Li Yixin Y Zhang Changlin C Yu Zhenglong Z Huang Wenlin W Sun Bing B Deng Wu-Guo WG
Oncotarget 20160801 33
Krüppel-like factor 4 (KLF4) is a transcription factor that contributes to diverse cellular processes and serves as a tumor suppressor or oncogene in various cancers. Previously, we have reported on the tumor suppressive function of KLF4 in lung cancer; however, its precise regulatory mechanism remains elusive. In this study, we found that KLF4 negatively regulated hTERT expression and telomerase activity in lung cancer cell lines and a mouse model. In addition, the KLF4 and hTERT expression lev ...[more]