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DMET™ (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine.

ABSTRACT: In the era of personalized medicine, high-throughput technologies have allowed the investigation of genetic variations underlying the inter-individual variability in drug pharmacokinetics/pharmacodynamics. Several studies have recently moved from a candidate gene-based pharmacogenetic approach to genome-wide pharmacogenomic analyses to identify biomarkers for selection of patient-tailored therapies. In this aim, the identification of genetic variants affecting the individual drug metabolism is relevant for the definition of more active and less toxic treatments. This review focuses on the potentiality, reliability and limitations of the DMET™ (Drug Metabolism Enzymes and Transporters) Plus as pharmacogenomic drug metabolism multi-gene panel platform for selecting biomarkers in the final aim to optimize drugs use and characterize the individual genetic background.

SUBMITTER: Arbitrio M 

PROVIDER: S-EPMC5288240 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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DMET™ (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine.

Arbitrio Mariamena M   Di Martino Maria Teresa MT   Scionti Francesca F   Agapito Giuseppe G   Guzzi Pietro Hiram PH   Cannataro Mario M   Tassone Pierfrancesco P   Tagliaferri Pierosandro P  

Oncotarget 20160801 33

In the era of personalized medicine, high-throughput technologies have allowed the investigation of genetic variations underlying the inter-individual variability in drug pharmacokinetics/pharmacodynamics. Several studies have recently moved from a candidate gene-based pharmacogenetic approach to genome-wide pharmacogenomic analyses to identify biomarkers for selection of patient-tailored therapies. In this aim, the identification of genetic variants affecting the individual drug metabolism is r  ...[more]

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