Ontology highlight
ABSTRACT:
SUBMITTER: Mamlouk S
PROVIDER: S-EPMC5288500 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Mamlouk Soulafa S Childs Liam Harold LH Aust Daniela D Heim Daniel D Melching Friederike F Oliveira Cristiano C Wolf Thomas T Durek Pawel P Schumacher Dirk D Bläker Hendrik H von Winterfeld Moritz M Gastl Bastian B Möhr Kerstin K Menne Andrea A Zeugner Silke S Redmer Torben T Lenze Dido D Tierling Sascha S Möbs Markus M Weichert Wilko W Folprecht Gunnar G Blanc Eric E Beule Dieter D Schäfer Reinhold R Morkel Markus M Klauschen Frederick F Leser Ulf U Sers Christine C
Nature communications 20170125
Genetic heterogeneity between and within tumours is a major factor determining cancer progression and therapy response. Here we examined DNA sequence and DNA copy-number heterogeneity in colorectal cancer (CRC) by targeted high-depth sequencing of 100 most frequently altered genes. In 97 samples, with primary tumours and matched metastases from 27 patients, we observe inter-tumour concordance for coding mutations; in contrast, gene copy numbers are highly discordant between primary tumours and m ...[more]