Ontology highlight
ABSTRACT:
SUBMITTER: Fukuda M
PROVIDER: S-EPMC5288656 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Fukuda Masatora M Umeno Hiromitsu H Nose Kanako K Nishitarumizu Azusa A Noguchi Ryoma R Nakagawa Hiroyuki H
Scientific reports 20170202
As an alternative to DNA mutagenesis, RNA mutagenesis can potentially become a powerful gene-regulation method for fundamental research and applied life sciences. Adenosine-to-inosine (A-to-I) RNA editing alters genetic information at the transcript level and is an important biological process that is commonly conserved in metazoans. Therefore, a versatile RNA-mutagenesis method can be achieved by utilising the intracellular RNA-editing mechanism. Here, we report novel guide RNAs capable of indu ...[more]