Rituximab therapy in pemphigus and other autoantibody-mediated diseases.
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ABSTRACT:
SUBMITTER: Ran NA
PROVIDER: S-EPMC5288686 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Rituximab therapy in pemphigus and other autoantibody-mediated diseases.
Ran Nina A NA Payne Aimee S AS
F1000Research 20170127
Rituximab, a monoclonal antibody targeting the B cell marker CD20, was initially approved in 1997 by the United States Food and Drug Administration (FDA) for the treatment of non-Hodgkin lymphoma. Since that time, rituximab has been FDA-approved for rheumatoid arthritis and vasculitides, such as granulomatosis with polyangiitis and microscopic polyangiitis. Additionally, rituximab has been used off-label in the treatment of numerous other autoimmune diseases, with notable success in pemphigus, a ...[more]
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