Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence.
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ABSTRACT:
SUBMITTER: Fellows CR
PROVIDER: S-EPMC5288717 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence.
Fellows Christopher R CR Williams Rebecca R Davies Iwan R IR Gohil Kajal K Baird Duncan M DM Fairclough John J Rooney Paul P Archer Charles W CW Khan Ilyas M IM
Scientific reports 20170202
In recent years it has become increasingly clear that articular cartilage harbours a viable pool of progenitor cells and interest has focussed on their role during development and disease. Analysis of progenitor numbers using fluorescence-activated sorting techniques has resulted in wide-ranging estimates, which may be the result of context-dependent expression of cell surface markers. We have used a colony-forming assay to reliably determine chondroprogenitor numbers in normal and osteoarthriti ...[more]
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