Ontology highlight
ABSTRACT:
SUBMITTER: Narula J
PROVIDER: S-EPMC5289222 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Narula Jatin J Kuchina Anna A Zhang Fang F Fujita Masaya M Süel Gürol M GM Igoshin Oleg A OA
Molecular systems biology 20160523 5
How can changes in growth rate affect the regulatory networks behavior and the outcomes of cellular differentiation? We address this question by focusing on starvation response in sporulating Bacillus subtilis We show that the activity of sporulation master regulator Spo0A increases with decreasing cellular growth rate. Using a mathematical model of the phosphorelay-the network controlling Spo0A-we predict that this increase in Spo0A activity can be explained by the phosphorelay protein accumula ...[more]