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Association of MHC region SNPs with irritant susceptibility in healthcare workers.

ABSTRACT: Irritant contact dermatitis is the most common work-related skin disease, especially affecting workers in "wet-work" occupations. This study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) within the major histocompatibility complex (MHC) and skin irritant response in a group of healthcare workers. 585 volunteer healthcare workers were genotyped for MHC SNPs and patch tested with three different irritants: sodium lauryl sulfate (SLS), sodium hydroxide (NaOH) and benzalkonium chloride (BKC). Genotyping was performed using Illumina Goldengate MHC panels. A number of SNPs within the MHC Class I (OR2B3, TRIM31, TRIM10, TRIM40 and IER3), Class II (HLA-DPA1, HLA-DPB1) and Class III (C2) genes were associated (p?

SUBMITTER: Yucesoy B

PROVIDER: S-EPMC5289286 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Association of MHC region SNPs with irritant susceptibility in healthcare workers.

Yucesoy Berran B Talzhanov Yerkebulan Y Michael Barmada M M Johnson Victor J VJ Kashon Michael L ML Baron Elma E Wilson Nevin W NW Frye Bonnie B Wang Wei W Fluharty Kara K Gharib Rola R Meade Jean J Germolec Dori D Luster Michael I MI Nedorost Susan S

Journal of immunotoxicology 20160603 5

Irritant contact dermatitis is the most common work-related skin disease, especially affecting workers in "wet-work" occupations. This study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) within the major histocompatibility complex (MHC) and skin irritant response in a group of healthcare workers. 585 volunteer healthcare workers were genotyped for MHC SNPs and patch tested with three different irritants: sodium lauryl sulfate (SLS), sodium hydroxide ...[more]

PMID: 27258892

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Genetic Basis of Irritant Susceptibility in Health Care Workers.

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Association analysis of the extended MHC region in celiac disease implicates multiple independent susceptibility loci.

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