Ontology highlight
ABSTRACT:
SUBMITTER: Dutta M
PROVIDER: S-EPMC5289750 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Dutta Mukta M Robertson Shelly J SJ Okumura Atsushi A Scott Dana P DP Chang Jean J Weiss Jeffrey M JM Sturdevant Gail L GL Feldmann Friederike F Haddock Elaine E Chiramel Abhilash I AI Ponia Sanket S SS Dougherty Jonathan D JD Katze Michael G MG Rasmussen Angela L AL Best Sonja M SM
Cell reports 20170101 3
The unprecedented 2013-2016 outbreak of Ebola virus (EBOV) resulted in over 11,300 human deaths. Host resistance to RNA viruses requires RIG-I-like receptor (RLR) signaling through the adaptor protein, mitochondrial antiviral signaling protein (MAVS), but the role of RLR-MAVS in orchestrating anti-EBOV responses in vivo is not known. Here we apply a systems approach to MAVS<sup>-/-</sup> mice infected with either wild-type or mouse-adapted EBOV. MAVS controlled EBOV replication through the expre ...[more]