Ontology highlight
ABSTRACT:
SUBMITTER: Henry WS
PROVIDER: S-EPMC5290090 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Henry Whitney S WS Laszewski Tyler T Tsang Tiffany T Beca Francisco F Beck Andrew H AH McAllister Sandra S SS Toker Alex A
Cancer research 20161209 3
Despite the high incidence of oncogenic mutations in PIK3CA, the gene encoding the catalytic subunit of PI3K, PI3K inhibitors have yielded little clinical benefit for breast cancer patients. Recent epidemiologic studies have suggested a therapeutic benefit from aspirin intake in cancers harboring oncogenic PIK3CA Here, we show that mutant PIK3CA-expressing breast cancer cells have greater sensitivity to aspirin-mediated growth suppression than their wild-type counterparts. Aspirin decreased viab ...[more]