Ontology highlight
ABSTRACT:
SUBMITTER: Jungen C
PROVIDER: S-EPMC5290156 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Jungen Christiane C Scherschel Katharina K Eickholt Christian C Kuklik Pawel P Klatt Niklas N Bork Nadja N Salzbrunn Tim T Alken Fares F Angendohr Stephan S Klene Christiane C Mester Janos J Klöcker Nikolaj N Veldkamp Marieke W MW Schumacher Udo U Willems Stephan S Nikolaev Viacheslav O VO Meyer Christian C
Nature communications 20170127
The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons. However, the impact on ventricular electrophysiology is unclear. Here we show that cardiac cholinergic neurons modulate ventricular electrophys ...[more]