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Association of CDKN2B-AS1 rs1333049 with Brain Diseases: A Case-control Study and a Meta-analysis.


ABSTRACT: Objective:CDKN2B-AS1 polymorphisms were shown to associate with the risk of stroke in European. The goal of this study was to evaluate the contribution of CDKN2B-AS1 rs1333049 to the risk of hemorrhagic stroke (HS) and brain tumor (BT) in Han Chinese. Methods:A total of 142 HSs, 115 BTs, and 494 controls were included in the current association study. The genotyping test was performed using the melting temperature shift method. Results:We failed to validate the association of CDKN2B-AS1 rs1333049 with the risk of brain disease. Significantly higher levels of low-density lipoprotein cholesterol (LDL-C) (p=0.027), high-density lipoprotein cholesterol (HDL-C) (p?0.001) and total cholesterol (TC) (p?0.001) were found in HSs in the genotype GG/GC carriers, but not the genotype CC carriers (p?0.05). The meta-analysis of 10 studies among 133,993 individuals concluded that rs1333049 of CDKN2B-AS1 gene was likely to increase a 16% incidence rate of cerebrovascular disease (CD) among various populations (odds ratio 1.16, 95% confidence interval 1.08-1.25; p?0.0001, random-effect method). Conclusion:Our case-control study identified rs1333049 genotypes showed different association with the concentration of the LDL-C, HDL-C and TC in the HS patients. Meta-analysis supported the association between rs1333049 and CD risk in various populations, although we were unable to observe association between rs1333049 and the risk of HSs in Han Chinese.

SUBMITTER: Zhao J 

PROVIDER: S-EPMC5290720 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Association of <i>CDKN2B-AS1</i> rs1333049 with Brain Diseases: A Case-control Study and a Meta-analysis.

Zhao Jikuang J   Wu Xizheng X   Nie Sheng S   Gao Xiang X   Sun Jie J   Li Keqin K   Zhang Tiefeng T   Huang Yi Y  

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 20170201 1


<h4>Objective</h4><i>CDKN2B-AS1</i> polymorphisms were shown to associate with the risk of stroke in European. The goal of this study was to evaluate the contribution of <i>CDKN2B-AS1</i> rs1333049 to the risk of hemorrhagic stroke (HS) and brain tumor (BT) in Han Chinese.<h4>Methods</h4>A total of 142 HSs, 115 BTs, and 494 controls were included in the current association study. The genotyping test was performed using the melting temperature shift method.<h4>Results</h4>We failed to validate th  ...[more]

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