YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.
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ABSTRACT:
SUBMITTER: Di Agostino S
PROVIDER: S-EPMC5290815 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.
Di Agostino Silvia S Sorrentino Giovanni G Ingallina Eleonora E Valenti Fabio F Ferraiuolo Maria M Bicciato Silvio S Piazza Silvano S Strano Sabrina S Del Sal Giannino G Blandino Giovanni G
EMBO reports 20151221 2
Mutant p53 proteins are present in more than half of human cancers. Yes-associated protein (YAP) is a key transcriptional regulator controlling organ growth, tissue homeostasis, and cancer. Here, we report that these two determinants of human malignancy share common transcriptional signatures. YAP physically interacts with mutant p53 proteins in breast cancer cells and potentiates their pro-proliferative transcriptional activity. We found YAP as well as mutant p53 and the transcription factor NF ...[more]
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