Expression of a beta-defensin mRNA, lingual antimicrobial peptide, in bovine mammary epithelial tissue is induced by mastitis.
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ABSTRACT:
SUBMITTER: Swanson K
PROVIDER: S-EPMC529112 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
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Expression of a beta-defensin mRNA, lingual antimicrobial peptide, in bovine mammary epithelial tissue is induced by mastitis.
Swanson Kara K Gorodetsky Stas S Good Laura L Davis Stephen S Musgrave David D Stelwagen Kerst K Farr Vicki V Molenaar Adrian A
Infection and immunity 20041201 12
The expression of a beta-defensin, the lingual antimicrobial peptide (LAP), in response to mastitis was investigated by real-time PCR of RNA from mastitic and control udder quarters. There was a positive relationship between somatic cell count in milk and LAP expression. In situ hybridization showed that LAP mRNA was expressed in epithelial cells of mastitic tissue. These results suggest that LAP plays a role in the innate immune response to mastitis. ...[more]
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