IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry.
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ABSTRACT:
SUBMITTER: Sanabria-Salas MC
PROVIDER: S-EPMC5291207 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry.
Sanabria-Salas María Carolina MC Hernández-Suárez Gustavo G Umaña-Pérez Adriana A Rawlik Konrad K Tenesa Albert A Serrano-López Martha Lucía ML Sánchez de Gómez Myriam M Rojas Martha Patricia MP Bravo Luis Eduardo LE Albis Rosario R Plata José Luis JL Green Heather H Borgovan Theodor T Li Li L Majumdar Sumana S Garai Jone J Lee Edward E Ashktorab Hassan H Brim Hassan H Li Li L Margolin David D Fejerman Laura L Zabaleta Jovanny J
Scientific reports 20170203
Single-nucleotide polymorphisms (SNPs) in cytokine genes can affect gene expression and thereby modulate inflammation and carcinogenesis. However, the data on the association between SNPs in the interleukin 1 beta gene (IL1B) and colorectal cancer (CRC) are conflicting. We found an association between a 4-SNP haplotype block of the IL1B (-3737C/-1464G/-511T/-31C) and CRC risk, and this association was exclusively observed in individuals with a higher proportion of African ancestry, such as indiv ...[more]
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