PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.
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ABSTRACT:
SUBMITTER: Belyk M
PROVIDER: S-EPMC5292032 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.
Belyk Michel M Kraft Shelly Jo SJ Brown Steven S
Journal of human genetics 20141218 3
PlexinA is a neuronal receptor protein that facilitates axon guidance during embryogenesis. This gene is associated with several neurological disorders including Alzheimer's disease, Parkinson's disease and autism. However, the effect of variants of PlexinA on brain structure remains unclear. We demonstrate that single-nucleotide polymorphisms within the intron and 3'-untranslated region segments of several human PlexinA genes alter the post-natal developmental trajectory of corpus callosum micr ...[more]
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