Sulfur dioxide prodrugs: triggered release of SO2via a click reaction.
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ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC5292044 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Sulfur dioxide prodrugs: triggered release of SO<sub>2</sub>via a click reaction.
Wang Wenyi W Ji Xingyue X Du Zhenming Z Wang Binghe B
Chemical communications (Cambridge, England) 20170101 8
Sulfur dioxide (SO<sub>2</sub>) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and H<sub>2</sub>S. Herein we describe a series of SO<sub>2</sub> prodrugs that are activated for SO<sub>2</sub> release via a bioorthogonal click reaction. The release rate can be tuned by adjusting the substituents on the prodrug. ...[more]
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