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Sulfur dioxide prodrugs: triggered release of SO2via a click reaction.

ABSTRACT: Sulfur dioxide (SO2) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and H2S. Herein we describe a series of SO2 prodrugs that are activated for SO2 release via a bioorthogonal click reaction. The release rate can be tuned by adjusting the substituents on the prodrug.

SUBMITTER: Wang W

PROVIDER: S-EPMC5292044 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Sulfur dioxide prodrugs: triggered release of SO2via a click reaction.

Wang Wenyi W Ji Xingyue X Du Zhenming Z Wang Binghe B

Chemical communications (Cambridge, England) 20170101 8

Sulfur dioxide (SO2) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and H2S. Herein we describe a series of SO2 prodrugs that are activated for SO2 release via a bioorthogonal click reaction. The release rate can be tuned by adjusting the substituents on the prodrug. ...[more]

PMID: 28070577

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