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Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strain.

ABSTRACT: Expression of the bla1 and bla2 genes in an archetypal Bacillus anthracis strain is insufficient for penicillin resistance. In a penicillin-resistant clinical isolate, both genes are highly transcribed, but bla1 is the major contributor to high-level resistance to ampicillin. Differential expression of the bla genes is dependent upon strain background.

SUBMITTER: Chen Y 

PROVIDER: S-EPMC529205 | biostudies-literature | 2004 Dec

REPOSITORIES: biostudies-literature

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Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strain.

Chen Yahua Y   Tenover Fred C FC   Koehler Theresa M TM  

Antimicrobial agents and chemotherapy 20041201 12

Expression of the bla1 and bla2 genes in an archetypal Bacillus anthracis strain is insufficient for penicillin resistance. In a penicillin-resistant clinical isolate, both genes are highly transcribed, but bla1 is the major contributor to high-level resistance to ampicillin. Differential expression of the bla genes is dependent upon strain background. ...[more]

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