Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strain.
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ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC529205 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Publications
Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strain.
Chen Yahua Y Tenover Fred C FC Koehler Theresa M TM
Antimicrobial agents and chemotherapy 20041201 12
Expression of the bla1 and bla2 genes in an archetypal Bacillus anthracis strain is insufficient for penicillin resistance. In a penicillin-resistant clinical isolate, both genes are highly transcribed, but bla1 is the major contributor to high-level resistance to ampicillin. Differential expression of the bla genes is dependent upon strain background. ...[more]
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