Ontology highlight
ABSTRACT:
SUBMITTER: Bodak M
PROVIDER: S-EPMC5292673 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Bodak Maxime M Cirera-Salinas Daniel D Yu Jian J Ngondo Richard P RP Ciaudo Constance C
FEBS open bio 20170111 2
A gene regulation network orchestrates processes ensuring the maintenance of cellular identity and genome integrity. Small RNAs generated by the RNAse III DICER have emerged as central players in this network. Moreover, deletion of <i>Dicer</i> in mice leads to early embryonic lethality. To better understand the underlying mechanisms leading to this phenotype, we generated <i>Dicer</i>-deficient mouse embryonic stem cells (mESCs). Their detailed characterization revealed an impaired differentiat ...[more]