Ontology highlight
ABSTRACT:
SUBMITTER: McNee G
PROVIDER: S-EPMC5292682 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
McNee G G Eales K L KL Wei W W Williams D S DS Barkhuizen A A Bartlett D B DB Essex S S Anandram S S Filer A A Moss P A H PA Pratt G G Basu S S Davies C C CC Tennant D A DA
Leukemia 20160711 2
Multiple myeloma (MM), an incurable plasma cell malignancy, requires localisation within the bone marrow. This microenvironment facilitates crucial interactions between the cancer cells and stromal cell types that permit the tumour to survive and proliferate. There is increasing evidence that the bone marrow mesenchymal stem cell (BMMSC) is stably altered in patients with MM-a phenotype also postulated to exist in patients with monoclonal gammopathy of undetermined significance (MGUS) a benign c ...[more]