Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen LA
PROVIDER: S-EPMC5293083 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nguyen Laura A LA Wang Jimin J Steitz Thomas A TA
Proceedings of the National Academy of Sciences of the United States of America 20170117 5
Small self-cleaving ribozymes have been discovered in all evolutionary domains of life. They can catalyze site-specific RNA cleavage, and as a result, they have relevance in gene regulation. Comparative genomic analysis has led to the discovery of a new class of small self-cleaving ribozymes named Pistol. We report the crystal structure of Pistol at 2.97-Å resolution. Our results suggest that the Pistol ribozyme self-cleavage mechanism likely uses a guanine base in the active site pocket to carr ...[more]