Ontology highlight
ABSTRACT:
SUBMITTER: Okkenhaug K
PROVIDER: S-EPMC5293166 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Okkenhaug Klaus K Graupera Mariona M Vanhaesebroeck Bart B
Cancer discovery 20160921 10
The PI3K pathway is hyperactivated in most cancers, yet the capacity of PI3K inhibitors to induce tumor cell death is limited. The efficacy of PI3K inhibition can also derive from interference with the cancer cells' ability to respond to stromal signals, as illustrated by the approved PI3Kδ inhibitor idelalisib in B-cell malignancies. Inhibition of the leukocyte-enriched PI3Kδ or PI3Kγ may unleash antitumor T-cell responses by inhibiting regulatory T cells and immune-suppressive myeloid cells. M ...[more]