Ontology highlight
ABSTRACT:
SUBMITTER: Lee W
PROVIDER: S-EPMC5293275 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Lee Wanho W Lim Sookkyung S Kim Yangjin Y
PloS one 20170206 2
Gliomas are malignant tumors that are commonly observed in primary brain cancer. Glioma cells migrate through a dense network of normal cells in microenvironment and spread long distances within brain. In this paper we present a two-dimensional multiscale model in which a glioma cell is surrounded by normal cells and its migration is controlled by cell-mechanical components in the microenvironment via the regulation of myosin II in response to chemoattractants. Our simulation results show that t ...[more]