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Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore.

ABSTRACT: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.

SUBMITTER: Zhang XD 

PROVIDER: S-EPMC5293734 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore.

Zhang Xiao-Dong XD   Wang Huasen H   Antaris Alexander L AL   Li Lulin L   Diao Shuo S   Ma Rui R   Nguyen Andy A   Hong Guosong G   Ma Zhuoran Z   Wang Joy J   Zhu Shoujun S   Castellano Joseph M JM   Wyss-Coray Tony T   Liang Yongye Y   Luo Jian J   Dai Hongjie H  

Advanced materials (Deerfield Beach, Fla.) 20160602 32

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI. ...[more]

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