Ontology highlight
ABSTRACT:
SUBMITTER: Castelo-Branco P
PROVIDER: S-EPMC5295385 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Castelo-Branco Pedro P Leão Ricardo R Lipman Tatiana T Campbell Brittany B Lee Donghyun D Price Aryeh A Zhang Cindy C Heidari Abolfazl A Stephens Derek D Boerno Stefan S Coelho Hugo H Gomes Ana A Domingos Celia C Apolonio Joana D JD Schäfer Georg G Bristow Robert G RG Schweiger Michal R MR Hamilton Robert R Zlotta Alexandre A Figueiredo Arnaldo A Klocker Helmut H Sültmann Holger H Tabori Uri U
Oncotarget 20160901 36
The identification of new biomarkers to differentiate between indolent and aggressive prostate tumors is an important unmet need. We examined the role of THOR (TERT Hypermethylated Oncological Region) as a diagnostic and prognostic biomarker in prostate cancer (PCa).We analyzed THOR in common cancers using genome-wide methylation arrays. Methylation status of the whole TERT gene in benign and malignant prostate samples was determined by MeDIP-Seq. The prognostic role of THOR in PCa was assessed ...[more]