Ontology highlight
ABSTRACT:
SUBMITTER: Ramachandran S
PROVIDER: S-EPMC5295402 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Ramachandran Sarath S Pan Catherine Qiurong CQ Zimmermann Sarah C SC Duvall Bridget B Tsukamoto Takashi T Low Boon Chuan BC Sivaraman J J
Oncotarget 20160901 36
Cancer cells employ glutaminolysis to provide a source of intermediates for their upregulated biosynthetic needs. Glutaminase, which catalyzes the conversion of glutamine to glutamate, is gaining increasing attention as a potential drug target. Small-molecule inhibitors such as BPTES and CB-839, which target the allosteric site of glutaminase with high specificity, demonstrate immense promise as anti-tumor drugs. Here, we report the study of a new BPTES analog, N,N'-(5,5'-(trans-cyclohexane-1,3- ...[more]