Ontology highlight
ABSTRACT:
SUBMITTER: Nam AR
PROVIDER: S-EPMC5295408 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nam Ah-Rong AR Kim Ji-Won JW Cha Yongjun Y Ha Hyerim H Park Ji Eun JE Bang Ju-Hee JH Jin Mei Hua MH Lee Kyung-Hun KH Kim Tae-Yong TY Han Sae-Won SW Im Seock-Ah SA Kim Tae-You TY Oh Do-Youn DY Bang Yung-Jue YJ
Oncotarget 20160901 36
Currently, there is no validated therapeutic target for biliary tract cancer (BTC). This study aimed to investigate the pre-clinical and clinical implication of HER2 as a therapeutic target in BTC. We established two novel HER2-amplified BTC cell lines, SNU-2670 and SNU-2773, from gallbladder cancer patients. SNU-2670 and SNU-2773 cells were sensitive to trastuzumab, dacomitinib, and afatinib compared with nine HER2-negative BTC cell lines. Dacomitinib and afatinib led to G1 cell cycle arrest in ...[more]