Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission.
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ABSTRACT:
SUBMITTER: Shyamsunder P
PROVIDER: S-EPMC5295412 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission.
Shyamsunder Pavithra P Esner Milan M Barvalia Maunish M Wu Yu Jun YJ Loja Tomáš T Boon Huat Bay HB Lleonart Matilde E ME Verma Rama S RS Krejci Lumir L Lyakhovich Alex A
Oncotarget 20160901 36
Fanconi anemia (FA) is a rare genetic disorder associated with bone-marrow failure, genome instability and cancer predisposition. Recently, we and others have demonstrated dysfunctional mitochondria with morphological alterations in FA cells accompanied by high reactive oxygen species (ROS) levels. Mitochondrial morphology is regulated by continuous fusion and fission events and the misbalance between these two is often accompanied by autophagy. Here, we provide evidence of impaired autophagy in ...[more]
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