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The putative tumor suppressor gene EphA7 is a novel BMI-1 target.

ABSTRACT: Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do not explain the full spectrum of BMI-1-mediated effects. Here we identify the putative tumor suppressor gene EphA7 as a novel direct BMI-1 target in neural cells and lymphocytes. EphA7 silencing has been reported in several different human tumor types including lymphomas, and our data suggest BMI1 overexpression as a novel mechanism leading to EphA7 inactivation via H3K27 trimethylation and DNA methylation.

SUBMITTER: Prost G

PROVIDER: S-EPMC5295425 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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The putative tumor suppressor gene EphA7 is a novel BMI-1 target.

Prost Gaëlle G Braun Sebastian S Hertwig Falk F Winkler Marcus M Jagemann Lucas L Nolbrant Sara S Leefa Isabelle V IV Offen Nils N Miharada Kenichi K Lang Stefan S Artner Isabella I Nuber Ulrike A UA

Oncotarget 20160901 36

Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do not explain the full spectrum of BMI-1-mediated effects. Here we identify the putative tumor suppress ...[more]

PMID: 27533460

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