Ontology highlight
ABSTRACT:
SUBMITTER: Diana G
PROVIDER: S-EPMC5295820 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Diana Giovanni G Patel Dhaval S DS Entchev Eugeni V EV Zhan Mei M Lu Hang H Ch'ng QueeLim Q
eLife 20170207
Neuroendocrine circuits encode environmental information via changes in gene expression and other biochemical activities to regulate physiological responses. Previously, we showed that <i>daf-7</i> TGFβ and <i>tph-1</i> tryptophan hydroxylase expression in specific neurons encode food abundance to modulate lifespan in <i>Caenorhabditis elegans</i>, and uncovered cross- and self-regulation among these genes (Entchev et al., 2015). Here, we now extend these findings by showing that these interacti ...[more]