Ontology highlight
ABSTRACT:
SUBMITTER: Oehlers SH
PROVIDER: S-EPMC5296212 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Oehlers Stefan H SH Flores Maria Vega MV Hall Christopher J CJ Wang Liuyang L Ko Dennis C DC Crosier Kathryn E KE Crosier Philip S PS
The FEBS journal 20170109 3
By performing two high-content small molecule screens on dextran sodium sulfate- and trinitrobenzene sulfonic acid-induced zebrafish enterocolitis models of inflammatory bowel disease, we have identified novel anti-inflammatory drugs from the John Hopkins Clinical Compound Library that suppress neutrophilic inflammation. Live imaging of neutrophil distribution was used to assess the level of acute inflammation and concurrently screen for off-target drug effects. Supporting the validity of our sc ...[more]