Ontology highlight
ABSTRACT:
SUBMITTER: Howe CG
PROVIDER: S-EPMC5296278 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Howe Caitlin G CG Liu Xinhua X Hall Megan N MN Ilievski Vesna V Caudill Marie A MA Malysheva Olga O Lomax-Luu Angela M AM Parvez Faruque F Siddique Abu B AB Shahriar Hasan H Uddin Mohammad N MN Islam Tariqul T Graziano Joseph H JH Costa Max M Gamble Mary V MV
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20161020 2
<h4>Background</h4>Posttranslational histone modifications (PTHMs) are altered by arsenic, an environmental carcinogen. PTHMs are also influenced by nutritional methyl donors involved in one-carbon metabolism (OCM), which may protect against epigenetic dysregulation.<h4>Methods</h4>We measured global levels of three PTHMs, which are dysregulated in cancers (H3K36me2, H3K36me3, H3K79me2), in peripheral blood mononuclear cells (PBMC) from 324 participants enrolled in the Folic Acid and Creatine Tr ...[more]