From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective.
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ABSTRACT:
SUBMITTER: Ghaddhab C
PROVIDER: S-EPMC5296294 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective.
Ghaddhab Chiraz C Vuissoz Jean-Marc JM Deladoëy Johnny J
Frontiers in endocrinology 20170208
The adrenocorticotropic hormone (ACTH) is a pituitary hormone derived from a larger peptide, the proopiomelanocortin (POMC), as are the MSHs (α-MSH, β-MSH, and γ-MSH) and the β-LPH-related polypeptides (Figure 1A). ACTH drives adrenal steroidogenesis and growth of the adrenal gland. ACTH is a 39 amino acid polypeptide that binds and activates its cognate receptor [melanocortin receptor 2 (MC2R)] through the two regions H<sub>6</sub>F<sub>7</sub>R<sub>8</sub>W<sub>9</sub> and K<sub>15</sub>K<sub> ...[more]
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