Ontology highlight
ABSTRACT:
SUBMITTER: Cackowski FC
PROVIDER: S-EPMC5296338 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Cackowski Frank C FC Eber Matthew R MR Rhee James J Decker Ann M AM Yumoto Kenji K Berry Janice E JE Lee Eunsohl E Shiozawa Yusuke Y Jung Younghun Y Aguirre-Ghiso Julio A JA Taichman Russell S RS
Journal of cellular biochemistry 20161110 4
Many prostate cancer (PCa) recurrences are thought to be due to reactivation of disseminated tumor cells (DTCs). We previously found a role of the TAM family of receptor tyrosine kinases TYRO3, AXL, and MERTK in PCa dormancy regulation. However, the mechanism and contributions of the individual TAM receptors is largely unknown. Knockdown of MERTK, but not AXL or TYRO3 by shRNA in PCa cells induced a decreased ratio of P-Erk1/2 to P-p38, increased expression of p27, NR2F1, SOX2, and NANOG, induce ...[more]