Ontology highlight
ABSTRACT:
SUBMITTER: Krishna BA
PROVIDER: S-EPMC5296658 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Krishna B A BA Spiess K K Poole E L EL Lau B B Voigt S S Kledal T N TN Rosenkilde M M MM Sinclair J H JH
Nature communications 20170202
Reactivation of human cytomegalovirus (HCMV) in transplant recipients can cause life-threatening disease. Consequently, for transplant recipients, killing latently infected cells could have far-reaching clinical benefits. In vivo, myeloid cells and their progenitors are an important site of HCMV latency, and one viral gene expressed by latently infected myeloid cells is US28. This viral gene encodes a cell surface G protein-coupled receptor (GPCR) that binds chemokines, triggering its endocytosi ...[more]