N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment.
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ABSTRACT:
SUBMITTER: Ghayor C
PROVIDER: S-EPMC5296751 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment.
Ghayor Chafik C Gjoksi Bebeka B Dong Jing J Siegenthaler Barbara B Caflisch Amedeo A Weber Franz E FE
Scientific reports 20170208
N,N-Dimethylacetamide (DMA) is a water-miscible solvent, FDA approved as excipient and therefore widely used as drug-delivery vehicle. As such, DMA should be devoid of any bioactivity. Here we report that DMA is epigenetically active since it binds bromodomains and inhibits osteoclastogenesis and inflammation. Moreover, DMA enhances bone regeneration in vivo. Therefore, our in vivo and in vitro data reveal DMA's potential as an anti-osteoporotic agent via the inhibition of osteoclast mediated bo ...[more]
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