Ontology highlight
ABSTRACT: Significance statement
More than 90% of ventral striatum is composed of two cell types, those expressing dopamine D1 or D2 receptors, which exert opposing roles on motivated behavior. Both cell types send GABAergic projections to the ventral pallidum and were found to differentially promote cue-induced reinstatement of cocaine seeking via the ventral pallidum. Furthermore, after cocaine self-administration, synaptic plasticity was selectively lost in D2, but not D1 inputs to the ventral pallidum. The selective impairment in D2 afferents may promote the influence of D1 inputs to drive relapse to cocaine seeking.
SUBMITTER: Heinsbroek JA
PROVIDER: S-EPMC5296778 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Heinsbroek Jasper A JA Neuhofer Daniela N DN Griffin William C WC Siegel Griffin S GS Bobadilla Ana-Clara AC Kupchik Yonatan M YM Kalivas Peter W PW
The Journal of neuroscience : the official journal of the Society for Neuroscience 20170101 4
Distinct populations of D1- and D2-dopamine receptor-expressing medium spiny neurons (D1-/D2-MSNs) comprise the nucleus accumbens, and activity in D1-MSNs promotes, whereas activity in D2-MSNs inhibits, motivated behaviors. We used chemogenetics to extend D1-/D2-MSN cell specific regulation to cue-reinstated cocaine seeking in a mouse model of self-administration and relapse, and found that either increasing activity in D1-MSNs or decreasing activity in D2-MSNs augmented cue-induced reinstatemen ...[more]