Ontology highlight
ABSTRACT:
SUBMITTER: Sharkey B
PROVIDER: S-EPMC5297495 | biostudies-literature | 2017 Feb/Mar
REPOSITORIES: biostudies-literature
Sharkey Beth B Pudi Sarat S Wallace Moyer Ian I Zhong Lihui L Prinz Bianka B Baruah Hemanta H Lynaugh Heather H Kumar Sampath S Wittrup K Dane KD Nett Juergen H JH
mAbs 20161212 2
Monovalent bispecific antibodies (BsAbs) are projected to have broad clinical applications due to their ability to bind two different targets simultaneously. Although they can be produced using recombinant technologies, the correct pairing of heavy and light chains is a significant manufacturing problem. Various approaches exploit mutations or linkers to favor the formation of the desired BsAb, but a format using a single common light chain has the advantage that no other modification to the ant ...[more]