Ontology highlight
ABSTRACT:
SUBMITTER: Valenti MT
PROVIDER: S-EPMC5297676 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Valenti Maria Teresa MT Dalle Carbonare Luca L Mottes Monica M
International journal of molecular sciences 20161227 1
This review focuses on the osteogenic differentiation of mesenchymal stem cells (MSC), bone formation and turn-over in good and ill skeletal fates. The interacting molecular pathways which control bone remodeling in physiological conditions during a lifelong process are described. Then, alterations of the molecular pathways regulating osteogenesis are addressed. In the aging process, as well as in glucocorticoid-induced osteoporosis, bone loss is caused not only by an unbalanced bone resorption ...[more]