Ontology highlight
ABSTRACT:
SUBMITTER: Mesentier-Louro LA
PROVIDER: S-EPMC5297732 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Mesentier-Louro Louise A LA De Nicolò Sara S Rosso Pamela P De Vitis Luigi A LA Castoldi Valerio V Leocani Letizia L Mendez-Otero Rosalia R Santiago Marcelo F MF Tirassa Paola P Rama Paolo P Lambiase Alessandro A
International journal of molecular sciences 20170105 1
Nerve growth factor (NGF) is suggested to be neuroprotective after nerve injury; however, retinal ganglion cells (RGC) degenerate following optic-nerve crush (ONC), even in the presence of increased levels of endogenous NGF. To further investigate this apparently paradoxical condition, a time-course study was performed to evaluate the effects of unilateral ONC on NGF expression and signaling in the adult retina. Visually evoked potential and immunofluorescence staining were used to assess axonal ...[more]