Ontology highlight
ABSTRACT:
SUBMITTER: Lee C
PROVIDER: S-EPMC5297802 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20170117 1
Glyoxal (GO) and methylglyoxal (MG), belonging to α-oxoaldehydes, are produced by organisms from bacteria to humans by glucose oxidation, lipid peroxidation, and DNA oxidation. Since glyoxals contain two adjacent reactive carbonyl groups, they are referred to as reactive electrophilic species (RES), and are damaging to proteins and nucleotides. Therefore, glyoxals cause various diseases in humans, such as diabetes and neurodegenerative diseases, from which all living organisms need to be protect ...[more]