Screening of Living Kidney Donors for Genetic Diseases Using a Comprehensive Genetic Testing Strategy.
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ABSTRACT:
SUBMITTER: Thomas CP
PROVIDER: S-EPMC5297870 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Screening of Living Kidney Donors for Genetic Diseases Using a Comprehensive Genetic Testing Strategy.
Thomas C P CP Mansilla M A MA Sompallae R R Mason S O SO Nishimura C J CJ Kimble M J MJ Campbell C A CA Kwitek A E AE Darbro B W BW Stewart Z A ZA Smith R J H RJ
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20160824 2
Related living kidney donors (LKDs) are at higher risk of end-stage renal disease (ESRD) compared with unrelated LKDs. A genetic panel was developed to screen 115 genes associated with renal diseases. We used this panel to screen six negative controls, four transplant candidates with presumed genetic renal disease and six related LKDs. After removing common variants, pathogenicity was predicted using six algorithms to score genetic variants based on conservation and function. All variants were e ...[more]
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