Ontology highlight
ABSTRACT:
SUBMITTER: Park J
PROVIDER: S-EPMC5297929 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Park Jimin J Kim Hyojin H Kim Suwon S Lee Daeun D Shin Dong Hae DH
Acta crystallographica. Section F, Structural biology communications 20170119 Pt 2
The Gram-negative bacterium Burkholderia pseudomallei is the causative agent of melioidosis. D-glycero-β-D-manno-Heptose-1-phosphate adenylyltransferase (HldC) is the fourth enzyme of the ADP-L-glycero-β-D-manno-heptose biosynthesis pathway, which produces an essential carbohydrate comprising the inner core of lipopolysaccharide. Therefore, HldC is a potential target of antibiotics against melioidosis. In this study, HldC from B. pseudomallei has been cloned, expressed, purified and crystallized ...[more]