Ontology highlight
ABSTRACT:
SUBMITTER: Srivastava S
PROVIDER: S-EPMC5298243 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Srivastava Shefali S Fergason-Cantrell Emily A EA Nahas Roger I RI Lever John R JR
Tetrahedron 20160804 40
Radiolabeled diprenorphine (DPN) and analogs are widely used ligands for non-invasive brain imaging of opioid receptors. To develop complementary radioligands optimized for studies of the peripheral opioid receptors, we prepared a pair of hydrophilic DPN derivatives, conjugated to the macrocyclic chelator DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), for complexation with trivalent metals. The non-radioactive indium (III) complexes, tethered to the C6-oxygen position of the DP ...[more]