Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity.
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ABSTRACT:
SUBMITTER: Friend DM
PROVIDER: S-EPMC5299005 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity.
Friend Danielle M DM Devarakonda Kavya K O'Neal Timothy J TJ Skirzewski Miguel M Papazoglou Ioannis I Kaplan Alanna R AR Liow Jeih-San JS Guo Juen J Rane Sushil G SG Rubinstein Marcelo M Alvarez Veronica A VA Hall Kevin D KD Kravitz Alexxai V AV
Cell metabolism 20161229 2
Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling contribute to physical inactivity in obesity. To investigate this, we quantified multiple aspects of dopamine signaling in lean and obese mice. We found that D2-type receptor (D2R) binding in the striatum, but not D1-type receptor binding or dopamine levels, was reduced in o ...[more]
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