Ontology highlight
ABSTRACT:
SUBMITTER: Howell JJ
PROVIDER: S-EPMC5299044 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Cell metabolism 20170112 2
Metformin is the most widely prescribed drug for the treatment of type 2 diabetes. However, knowledge of the full effects of metformin on biochemical pathways and processes in its primary target tissue, the liver, is limited. One established effect of metformin is to decrease cellular energy levels. The AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) are key regulators of metabolism that are respectively activated and inhibited in acute response ...[more]