Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system.
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ABSTRACT:
SUBMITTER: Giardino WJ
PROVIDER: S-EPMC5299395 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system.
Giardino W J WJ Rodriguez E D ED Smith M L ML Ford M M MM Galili D D Mitchell S H SH Chen A A Ryabinin A E AE
Translational psychiatry 20170131 1
Midbrain neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are activated by alcohol, and enriched with stress-responsive neuropeptide modulators (including the paralog of corticotropin-releasing factor, urocortin-1). Evidence suggests that EWcp neurons promote behavioral processes for alcohol-seeking and consumption, but a definitive role for these cells remains elusive. Here we combined targeted viral manipulations and gene array profiling of EWcp neurons with mass behavioral ...[more]
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