Ontology highlight
ABSTRACT:
SUBMITTER: Zheng K
PROVIDER: S-EPMC5299514 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Zheng Kaiyu K Jensen Thomas P TP Savtchenko Leonid P LP Levitt James A JA Suhling Klaus K Rusakov Dmitri A DA
Scientific reports 20170209
Neural activity relies on molecular diffusion within nanoscopic spaces outside and inside nerve cells, such as synaptic clefts or dendritic spines. Measuring diffusion on this small scale in situ has not hitherto been possible, yet this knowledge is critical for understanding the dynamics of molecular events and electric currents that shape physiological signals throughout the brain. Here we advance time-resolved fluorescence anisotropy imaging combined with two-photon excitation microscopy to m ...[more]