Ontology highlight
ABSTRACT:
SUBMITTER: Sangrithi MN
PROVIDER: S-EPMC5300051 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Sangrithi Mahesh N MN Royo Helene H Mahadevaiah Shantha K SK Ojarikre Obah O Bhaw Leena L Sesay Abdul A Peters Antoine H F M AH Stadler Michael M Turner James M A JM
Developmental cell 20170126 3
Somatic X dosage compensation requires two mechanisms: X inactivation balances X gene output between males (XY) and females (XX), while X upregulation, hypothesized by Ohno and documented in vivo, balances X gene with autosomal gene output. Whether X dosage compensation occurs in germ cells is unclear. We show that mouse and human germ cells exhibit non-canonical X dosage states that differ from the soma and between the sexes. Prior to genome-wide reprogramming, X upregulation is present, consis ...[more]