Ontology highlight
ABSTRACT:
SUBMITTER: Toots M
PROVIDER: S-EPMC5300127 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Toots Mart M Ustav Mart M Männik Andres A Mumm Karl K Tämm Kaido K Tamm Tarmo T Ustav Ene E Ustav Mart M
PLoS pathogens 20170209 2
Human papillomaviruses (HPVs) are oncogenic viruses that cause numerous different cancers as well as benign lesions in the epithelia. To date, there is no effective cure for an ongoing HPV infection. Here, we describe the generation process of a platform for the development of anti-HPV drugs. This system consists of engineered full-length HPV genomes that express reporter genes for evaluation of the viral copy number in all three HPV replication stages. We demonstrate the usefulness of this syst ...[more]